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Huntington’s Disease
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Gatto, E. M., Rojas, N. G., Persi, G., Etcheverry, J. L., Cesarini, M. E., & Perandones, C. (2020). Huntington’s disease: Advances in the understanding of its mechanisms. Clinical Parkinsonism & Related Disorders, 3, 100056. https://doi.org/10.1016/j.prdoa.2020.100056
The research by Gatto et al. (2020), aimed to make a compilation of new discoveries on the pathogenesis of Huntington’s Disease. The study considers the genetic and molecular biology mechanisms involved in the neurodegenerative process of the pathology. As well as the main pathogenic mechanisms involved in the progression of the disease are described in detail. The type of research performed was a review of the literature that incorporated studies published in peer-reviewed journals in the last 20 years. This study is useful for the research to be carried out because it has updated and relevant information on the pathophysiological mechanisms involved in the progression of Huntington’s Disease. Therefore, it will provide valuable information to understand the pathophysiology and the genetic mechanisms involved in the pathology.
Kumar, A., Kumar, V., Singh, K., Kumar, S., Kim, Y. S., Lee, Y. M., & Kim, J. J. (2020). Therapeutic advances for Huntington’s Disease. Brain Sciences, 10(1), 43. https://doi.org/10.3390/brainsci10010043
The article published by Kumar et al. (2020), had the purpose of reviewing the therapeutic approaches currently available for Huntington’s disease. The authors conducted a literature review that included studies published in English-language peer-reviewed journals over the past 25 years. In addition to addressing the most innovative therapeutic approaches, a review of the pathophysiology and the genetic factors involved in the development of the disease is also carried out. Being a study focused on treatment and new therapeutic approaches, the article is useful for future research because it provides an updated conceptual framework on this topic.
Pan, L., & Feigin, A. (2021). Huntington’s Disease: New frontiers in therapeutics. Current Neurology and Neuroscience Reports, 21(3). https://doi.org/10.1007/s11910-021-01093-3
The study carried out by Pan & Feigin (2021) focused on analyzing and evaluating the therapeutic options available for patients with Huntington’s Disease, as well as analyzing the promising therapies that are in development. The article discusses therapeutic alternatives such as direct DNA/gene therapy, therapies targeting aberrant pathways, and RNA modulation. In addition, a theoretical framework of the pathology and its causes is also provided. The type of research is of the literature review type, it collects information from articles published in the last 25 years in scientific journals of high academic prestige and reviewed by peers. The research is important for the article that will be performed because it offers valuable information about Huntington’s Disease, its biology, genetics and addresses the present and future of treatment.
Pooja, M., Prince, R., & Amit, S. (2018). A clinical review on Huntington’s Disease. Glob J Pharmaceu, 6(4), 1–5. https://juniperpublishers.com/gjpps/pdf/GJPPS.MS.ID.555693.pdf
Research published by Pooja et al. (2018), addressed Huntington’s Disease from a clinical point of view. The study focused on providing information about the disease, its history, epidemiology, signs, symptoms, diagnosis, and management. The clinical and relevant aspects of the information are addressed in a detailed and simple way. The article published by the authors was a literature review and includes articles in English published in the last 30 years in peer-reviewed journals. This research is relevant to the study to be carried out because it provides a theoretical framework on Huntington’s Disease from a clinical perspective. Therefore, it will contribute to understanding and considering the relevant aspects of the disease for daily practice.
Tabrizi, S. J., Flower, M. D., Ross, C. A., & Wild, E. J. (2020). Huntington disease: New insights into molecular pathogenesis and therapeutic opportunities. Nature Reviews Neurology, 16(10), 529–546. https://doi.org/10.1038/s41582-020-0389-4
In the article published by Tabrizi et al. (2020) the new existing knowledge about the pathophysiological mechanism of the disease is analyzed, and it is evaluated how this knowledge could be used for new therapeutic approaches in the future. The research carried out was a review of the literature that incorporated information from studies published in peer-reviewed journals during the last 20 years. The study reveals the genetic and molecular biological mechanisms that cause the signs and symptoms of Huntington’s disease. As well as explaining the role of DNA modulation and repair in pathophysiology. This research is useful to the pathology project because it provides new information on the pathophysiology of Huntington’s disease.
References
Gatto, E. M., Rojas, N. G., Persi, G., Etcheverry, J. L., Cesarini, M. E., & Perandones, C. (2020). Huntington disease: Advances in the understanding of its mechanisms. Clinical Parkinsonism & Related Disorders, 3, 100056. https://doi.org/10.1016/j.prdoa.2020.100056
Kumar, A., Kumar, V., Singh, K., Kumar, S., Kim, Y. S., Lee, Y. M., & Kim, J. J. (2020). Therapeutic advances for Huntington’s Disease. Brain Sciences, 10(1), 43. https://doi.org/10.3390/brainsci10010043
Pan, L., & Feigin, A. (2021). Huntington’s Disease: New frontiers in therapeutics. Current Neurology and Neuroscience Reports, 21(3). https://doi.org/10.1007/s11910-021-01093-3
Pooja, M., Prince, R., & Amit, S. (2018). A clinical review on Huntington Disease. Glob J Pharmaceu, 6(4), 1–5. https://juniperpublishers.com/gjpps/pdf/GJPPS.MS.ID.555693.pdf
Tabrizi, S. J., Flower, M. D., Ross, C. A., & Wild, E. J. (2020). Huntington disease: New insights into molecular pathogenesis and therapeutic opportunities. Nature Reviews Neurology, 16(10), 529–546. https://doi.org/10.1038/s41582-020-0389-4