The 1st part is to read the material and then write the initial discussion post. The 2nd part is to write a short reply to 3 classmates posts. Once the initial post is completed I will post here 3 other classmates posts for you to write a short reply to.
The first part of the assignment must be completed within 24 hours.
Assignment:
Malformations in the lymphatic system, called lymphangiomas, are overgrowths of the one-way lymph channels. Rarely, in infants and children, these channels grow abnormally large and cause deformity or death if the overgrowth chokes off a child’s airway or interferes with other aspects of heart and lung function. The deformity tends to grow with the child, worsening over time and is difficult to treat.
Physicians at Lucile Packard Children’s Hospital at Stanford (Links to an external site.) discovered, essentially by accident, that a common drug – sildenafil, a.k.a. Viagra – appears to shrink the overgrown vessels. They gave sildenafil to a child with a severe lymphangioma to treat another condition, pulmonary hypertension, and noticed that the lymph malformation shrank significantly. Unfortunately, the child’s underlying condition was so severe that she later died; however, two subsequent patients have done well on the medication.
“There has been no medical treatment for lymphangiomas; now all of a sudden there may be one,” said Al Lane, MD, a co-author on the NEJM letter published January 2012 and an investigator on the lymphangioma research now being conducted. The mechanism by which the drug could resolve the malformations is not known, however, there’s a possibility that sildenafil may help to open and drain the channels,” Lane said.
The drug (Viagra) has been used to treat pulmonary hypertension in children. Its typical side effects in children are nausea, headaches and cold-like symptoms such as a runny nose or fever, Lane said. Spontaneous erections are possible but are an infrequent side effect. Discuss your thoughts on studying and utilizing Viagra as a treatment for lymphangioma and its side effects in children.
Source: Lane, A. (2012, January 26). Sildenfil for Severe Lymphatic Malformations. (Links to an external site.) New England Journal of Medicine, 366. Retrieved from New England Journal of Medicine <\/p>\n","protected":false},"excerpt":{"rendered":"
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